|
KMID : 1225720150070060573
|
|
Allergy, Asthma & Immunology Research : AAIR
2015 Volume.7 No. 6 p.573 ~ p.582
|
|
|
Prenatal Particulate Matter/Tobacco Smoke Increases Infants' Respiratory Infections: COCOA Study
|
|
Yang Song-I
Kim Byoung-Ju
Lee So-Yeon
Kim Hyo-Bin
Lee Cheol-Min
Yu Jin-Ho
Kang Mi-Jin
Yu Ho-Sung
Lee Eun
Jung Young-Ho
Kim Hyung-Young
Seo Ju-Hee
Kwon Ji-Won
Song Dae-Jin
Jang Gwang-Cheon
Kim Woo-Kyung
Shim Jung-Yeon
Lee Soo-Young
Yang Hyeon-Jong
Suh Dong-In
Hong Seo-Ah
Choi Kil-Yong
Shin Youn-Ho
Ahn Kang-Mo
Kim Kyung-Won
Kim Eun-Jin
Hong Soo-Jong
|
|
|
Abstract
|
|
|
Purpose: To investigate whether prenatal exposure to indoor fine particulate matter (PM2.5) and environmental tobacco smoke (ETS) affects susceptibility to respiratory tract infections (RTIs) in infancy, to compare their effects between prenatal and postnatal exposure, and to determine whether genetic factors modify these environmental effects.
Methods: The study population consisted of 307 birth cohort infants. A diagnosis of RTIs was based on parental report of a physician's diagnosis. Indoor PM2.5 and ETS levels were measured during pregnancy and infancy. TaqMan was used for genotyping of nuclear factor erythroid 2-related factor (Nrf2) (rs6726395), glutathione-S-transferase-pi (GSTP) 1 (rs1695), and glutathione-S-transferase-mu (GSTM) 1. Microarrays were used for genome-wide methylation analysis.
Results: Prenatal exposure to indoor PM2.5 increased the susceptibility of lower RTIs (LRTIs) in infancy (adjusted odds ratio [aOR]=2.11). In terms of combined exposure to both indoor PM2.5 and ETS, prenatal exposure to both pollutants increased susceptibility to LRTIs (aOR=6.56); however, this association was not found for postnatal exposure. The Nrf2 GG (aOR=23.69), GSTM1 null (aOR=8.18), and GSTP1 AG or GG (aOR=7.37) genotypes increased the combined LRTIs-promoting effects of prenatal exposure to the 2 indoor pollutants. Such effects of prenatal indoor PM2.5 and ETS exposure were not found for upper RTIs.
Conclusions: Prenatal exposure to both indoor PM2.5 and ETS may increase susceptibility to LRTIs. This effect can be modified by polymorphisms in reactive oxygen species-related genes.
|
|
|
KEYWORD
|
|
|
Prenatal exposure, particulate matter, tobacco smoke, respiratory tract infections, polymorphism, methylation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|